OREGONIA. Beautiful natural surroundings highlight this historic Native American site. Dating back 2,000 years, the site is comprised of several ceremonial mounds, and about 18,000 feet of earthen wall, portions of which were used along with the moon and sun as a calendar. In the museum, a range of artifacts including stone tools and bones provide a fascinating look at Native American history in the region; the grounds feature numerous trails, a scenic overlook, and picnic spots.

This 1833 home was originally built for the president of Lane Seminary, who happened to be Dr. Lyman Beecher, father of famed author and abolitionist Harriet Beecher Stowe. She lived in the house for about two years, until she married professor Calvin E. Stowe. Today, the house functions as cultural center to promote African-American history.

NORTH BEND. Ninth President of the US, William Henry Harrison spent the better part of his life in the Midwest, where he became known as a fearless and talented military leader. Harrison first earned acclaim for his hard-won victory in the Battle of Tippecanoe, and then during the War of 1812, won further accolades for his leadership of the battalions which defeated the British and Native American armies, and is credited with killing Indian chief Tecumseh. Elected President in 1841, Harrison died of pneumonia just a month after entering office. His tomb, topped by a 60 foot stone obelisk, is on Mt Nebo in North Bend.

DOWNTOWN. Opened in 1866, this impressive bridge was the first to cross the Ohio River, connecting the bustling city of Cincinnati to its neighbors in Kentucky, and it continues to be a much-loved city landmark. If the name John A. Roebling sounds familiar, it should. After he constructed the Cincinnati bridge, he went on to design the world-famous Brooklyn Bridge.

COVINGTON. You will be in awe upon entering this beautiful cathedral. There are 82 stained glass windows, one of which is the largest in the world. The tabernacle in the Blessed Sacrament Chapel is plated in gold and set with semiprecious gems. The outside is a superb example of Gothic architecture. One of just 35 cathedral basilicas in the US. Brochures are available for self-guided tours; groups of 10 or more can arrange docent-guided tours with 2-weeks notice.